Obesity is a growing global issue, affecting over 40% of the population in some high-income countries, including the US and rising fast in low-and-middle-income countries. It is deeply interconnected with various factors, and targeting weight alone risks overlooking these complex, interconnected drivers. This paper explores a broader and more systemic approach – advancing metabolic health across multiple indicators. Taking this approach may unlock 3.5x more healthy life years than targeting obesity alone. It could also eventually lead to a ~$5.7 trillion GDP uplift by 2050, representing ~3% of global GDP.